Table 1.
The CDK1 regulatory kinome.
| Gene name | CDK1 phosphosite | Effect | Evidence (PMID) |
|---|---|---|---|
| CDK7 | Thr161 | up-regulates activity | 8344251 |
| CDC25A | Thr14-Tyr15 | up-regulates activity | 10454565 |
| CDC25C | Thr14-Tyr15 | up-regulates activity | 19574738 |
| EIF2AK2 | Tyr4 | down-regulates | 20395957 |
| PKMYT1 | Thr14-Tyr15 | down-regulates | 9001210 |
| ERBB2 | Tyr15 | down-regulates activity | 12049736 |
| WEE1 | Tyr15 | down-regulates activity | 16096060 |
| GRK7 | Thr5 | unknown | 36631611 |
| PLK2/3 | Thr5 | unknown | 36631611 |
| OSR1 | Thr240 | unknown | 36631611 |
| SLK | Thr240 | unknown | 36631611 |
| TAO1/3 | Thr240 | unknown | 36631611 |
| DYRK4 | Thr222 | unknown | 36631611 |
| JNK1/2/3 | Thr222 | unknown | 36631611 |
| MOK | Thr222 | unknown | 36631611 |
| MEKK2 | Thr141 | unknown | 36631611 |
| MST4 | Thr141 | unknown | 36631611 |
| MYO3A | Thr141 | unknown | 36631611 |
| GSK3A | Ser46 | unknown | 36631611 |
| PRP4 | Ser46 | unknown | 36631611 |
| TTBK2 | Ser46 | unknown | 36631611 |
| FAM20C | Ser39 | unknown | 36631611 |
| GRK6 | Ser39 | unknown | 36631611 |
| AURC | Ser277 | unknown | 36631611 |
| MYLK4 | Ser277 | unknown | 36631611 |
| PKG2 | Ser277 | unknown | 36631611 |
| ERK5 | Ser265 | unknown | 36631611 |
| TTBK1 | Ser265 | unknown | 36631611 |
| NDR2 | Ser2498 | unknown | 36631611 |
| MTOR | Ser248 | unknown | 36631611 |
| PAK4/5/6 | Ser248 | unknown | 36631611 |
| CK1G3/2 | Ser233 | unknown | 36631611 |
| IKKA | Ser233 | unknown | 36631611 |
| PLK2 | Ser233 | unknown | 36631611 |
| CAMK2B | Ser208 | unknown | 36631611 |
| CHK1 | Ser208 | unknown | 36631611 |
| CK2A1/2 | Ser208 | unknown | 36631611 |
| CDKL5 | Ser178 | unknown | 36631611 |
| DSTYK | Ser178 | unknown | 36631611 |
| ERK1/5/7 | Ser178 | unknown | 36631611 |
| CDK12/13/19 | Ser171 | unknown | 36631611 |
| CDK8/9 | Ser171 | unknown | 36631611 |
| P38A | Ser171 | unknown | 36631611 |
| CSNK2A1 | Ser39 | up-regulates | 15788687 |