Table 2.
The CDK1 substrates.
| Gene name | Effect | Phosphosite | Evidence (PMID) |
|---|---|---|---|
| ABI1 | inhibition | S216 | 21900237 |
| AKAP12 | activation | T767 | 23063527 |
| ANAPC1 | activation | S355 | 14657031 |
| APLP2 | unknown | T736 | 9109675 |
| AR | activation | S83 | 21799006 |
| ATAD5 | inhibition | S653 | 31875566 |
| BAD | activation | S91 | 24677263 |
| BCL2 | activation | T56 | 10766756 |
| BCL2L11 | activation | S104 | 22071694 |
| BIRC5 | activation | T34 | 11861764 |
| BRCA1 | activation | S1191-S1189-S1497 | 19683496 |
| BUB1 | activation | T609 | 16760428 |
| BUB1B | activation | T620 | 17785528 |
| CASP8 | inhibition | S387 | 20937773 |
| CASP9 | inhibition | T125 | 16287866 |
| CC2D1A | activation | S208 | 20171170 |
| CDC16 | activation | S560 | 14657031 |
| CDC23 | activation | T565 | 14657031 |
| CDC25A | activation | S116-S18 | 12411508 |
| CDC25B | activation | S321-S160 | 20801879;12107172 |
| CDC25C | opposite effects | S214-S168-T48-T67-S122-T130 | 10864927; 10037602 |
| CDC27 | activation | T446-S426 | 14657031 |
| CDC7 | activation | T376 | 10846177 |
| CDKN1B | inhibition | T187 | 10931950 |
| CEP55 | inhibition | S428-S425 | 16198290 |
| CHEK1 | activation | S301-S286 | 21765472 |
| CKAP2 | activation | T623 | 19369249 |
| CSNK2A1 | activation | S362-S370-T360-T344 | 19941816;7592773 |
| CSNK2B | activation | S209 | 7578274 |
| CUX1 | inhibition | S1237-S1270 | 11584018 |
| DCTN6 | activation | T186 | 23455152 |
| DDX3X | inhibition | T323-T204 | 16280325 |
| DLG1 | unknown | S443-S158 | 19066288 |
| DNMT1 | activation | S154 | 21565170 |
| DUT | activation | S11 | 8631817 |
| E2F1 | activation | S337-S332 | 8087847 |
| ECT2 | opposite effects | T848-T444-T373 | 16247472; 16170345 |
| EEF1D | unknown | S133 | 12551973 |
| EEF2K | inhibition | S359 | 18337751 |
| EGFR | inhibition | S1026 | 8360196 |
| EIF4EBP1 | inhibition | T70 | 11553333 |
| EIF4G2 | activation | T508 | 29530922 |
| EPN1 | inhibition | S382 | 10764745 |
| ERCC6L | activation | T1063 | 17218258 |
| ESPL1 | inhibition | S1126 | 11747808 |
| EZH2 | inhibition | T487-T345 | 21659531 |
| FANCG | activation | S387 | 15367677 |
| FEN1 | inhibition | S187 | 12853968 |
| FOXK2 | activation | S428-S373 | 20810654 |
| FOXM1 | activation | T611-S251 | 19737929 |
| FOXO1 | inhibition | S249 | 18408765 |
| GOLGA2 | inhibition | S37 | 9753325 |
| GORASP1 | inhibition | S274 | 15834132 |
| HMGA1 | inhibition | T53-T78-S36 | 17960875;1939057 |
| HMGA2 | inhibition | S59-S44 | 10636877 |
| INCENP | activation | T412 | 16378098 |
| IREB2 | inhibition | S157 | 18574241 |
| KAT5 | activation | S90-S86 | 16103124 |
| KAT7 | activation | T88-T85 | 18250300 |
| KHDRBS1 | unknown | T317 | 9315091 |
| KIF11 | activation | T926 | 9235942 |
| KIF20B | activation | T1644 | 11470801 |
| KIF22 | activation | T463 | 12727876 |
| KIF2C | inhibition | T537 | 20368358 |
| KIF4A | activation | T1161 | 29771379 |
| KMT5A | activation | S100 | 20966048 |
| KRT18 | activation | S34 | 9524113 |
| KRT8 | activation | S432 | 9524113 |
| LATS1 | activation | S613 | 12372621 |
| LBR | inhibition | S71 | 14718546 |
| LIG1 | activation | S76 | 12851383 |
| LMNA | activation | S390-S392-S22 | 18815303 |
| MAP2K1 | inhibition | T292-T286 | 8114697 |
| MAP4 | inhibition | S696-S787 | 9398320;10791892 |
| MAPK6 | activation | S684-T698-S688-ST05 | 20236090 |
| MASTL | activation | T194-T207 | 22354989 |
| MCL1 | inhibition | T92 | 20526282 |
| MCM4 | inhibition | T19 | 12714602 |
| MDM4 | inhibition | S96 | 15735705 |
| MPLKIP | activation | T120-S104-S93 | 17310276 |
| MYOD1 | inhibition | S200-S5 | 21902831;14749395 |
| NCOA3 | inhibition | S728 | 22163316 |
| NFAT5 | activation | T135 | 21209322 |
| NIFK | activation | T238 | 16244663 |
| NINL | activation | S185 | 20890132 |
| NME1 | activation | S120 | 18234856 |
| NPM1 | inhibition | S70-T237-T234-T199 | 19933706;12058066; |
| NSFL1C | inhibition | S140 | 12810701 |
| NUCKS1 | inhibition | S181 | 12413487 |
| NUMA1 | inhibition | T2055 | 23921553 |
| NUP210 | activation | S1881 | 8672508 |
| NUP50 | inhibition | S221 | 19767751 |
| NUP98 | inhibition | S612-S623-T670 | 21335236 |
| NUSAP1 | inhibition | T338-T300 | 22101338 |
| ORC1 | activation | T375-S258-S273 | 11931757 |
| PAPOLA | activation | S537-S558-S545 | 34048556 |
| PBK | unknown | T9 | 15541388 |
| PIK3C2A | inhibition | S259 | 12719431 |
| PIK3C3 | inhibition | T159 | 20513426 |
| PITPNM1 | activation | S382-T287 | 15125835 |
| PLEC | inhibition | T4539 | 8626512 |
| PPP1CA | inhibition | T320 | 12202491 |
| PRDX1 | inhibition | T90 | 11986303 |
| PRPS1 | activation | S103 | 31253668 |
| PTHLH | inhibition | T121 | 10373465 |
| PTPN1 | unknown | S386 | 8491187 |
| PTPN2 | unknown | S304 | 15030318 |
| PTTG2 | activation | S165 | 10656688 |
| RAB5B | unknown | S123 | 10403367 |
| RAD9A | activation | S277-S328-T355-S336-T292 | 12734188 |
| RANBP2 | activation | S2276-S2251-S2246-S2280 | 26051540 |
| RANGAP1 | activation | S428-T409-S442-T2153 | 15037602 |
| RAP1GAP | unknown | S484 | 1406653 |
| RB1 | inhibition | S249-S811-S807-T252-T373 | 1756735 |
| RCC1 | activation | S2-S381-S11-T274 | 15014043 |
| REPS2 | inhibition | S463 | 10764745 |
| RFC1 | inhibition | T506 | 12930972 |
| RNMT | activation | T77 | 26942677 |
| RPA2 | activation | S23-S29 | 1318195 |
| RPS3 | activation | T221 | 21871177 |
| RPS6KB1 | activation | T444-S434-S394 | 11705993;12586835;9271440 |
| RPTOR | unknown | S696-T706 | 20169205 |
| RRM2 | inhibition | S20-T33 | 9990288;22632967 |
| RUNX1 | opposite effects | S276-S21-T273-S266-S249-S397 | 1705873; 12058866; 11278991 |
| RUNX2 | activation | S465 | 16407259 |
| SAMHD1 | inhibition | T592 | 23602554 |
| SGO1 | activation | T346 | 24055156 |
| SIRT1 | activation | S540 | 19107194 |
| SIRT2 | inhibition | S368 | 17488717 |
| SLBP | inhibition | T62 | 18490441 |
| SP1 | activation | T739 | 20150555 |
| SQSTM1 | activation | T269-S272 | 20974803 |
| SREBF1 | activation | S439 | 16880739 |
| STIM1 | inhibition | S668 | 19881501 |
| STIP1 | inhibition | T332-S189-T198 | 14754904 |
| SUN1 | inhibition | S334-S48 | 25482198 |
| SYN3 | activation | S470 | 14732590 |
| TK1 | inhibition | S13 | 14697231 |
| TOP2A | unknown | S1247-S1361-S1354-S1393 | 7635160 |
| TP53 | activation | S315 | 24173284 |
| TP53BP1 | inhibition | S1678 | 30685087 |
| TP73 | inhibition | T86 | 12676926 |
| TPX2 | inhibition | T72 | 25688093 |
| TSC1 | inhibition | T1047-T417-S584 | 14551205 |
| UBA1 | activation | S835-S4 | 7724583;9099746 |
| UBE2A | activation | S120 | 11953320 |
| UBXN2B | inhibition | S56-T59 | 23500464 |
| USP16 | activation | S552 | 24013421 |
| VCPIP1 | inhibition | T761-S768 | 23500464 |
| VIM | inhibition | S55 | 7983050 |
| WAC | activation | T244-T471-T482-T457 | 30021153 |
| WEE1 | inhibition | S123 | 16085715 |
| ZC3HC1 | inhibition | S395 | 17389604 |
CDK1 direct substrates were extracted from the SIGNOR database [13] and reported.