TABLE 3.

Chemo-sensitizing effects of resveratrol.

Treatment	Type of cancer	Effects	References
Adriamycin + Resveratrol and quercetin Polymeric micelles (nanostructures) Pluronics®	Resistant ovarian cancer xenograft models	They reduce cardiotoxicity induced by adriamycin and, at the same time, act as chemosensitizers	Fatease et al. (2019)
Cisplatin + Resveratrol	Breast cancer Cisplatin-resistant MDA-MB-231 (cisR)	It improved chemosensitivity by inhibiting IL-6 production and STAT3 activation and reversing macrophage polarization	Cheuk et al. (2022)
Gemcitabine + Resveratrol	Pancreatic cancer: MiaPaCa-2 and Panc-1 And KPC mouse model	RSV inhibited lipid synthesis through SREBP1. This decreased the sphere-forming ability and suppressed the expression of CSC markers	Zhou et al. (2019)
Temozolomide + Resveratrol	Glioblastoma: A172 and LN428 cells	RSV negatively regulated STAT3, inhibited cell proliferation and migration, and induced apoptosis, accompanied by elevated levels of its negative regulators: PIAS3, SHP1, SHP2, and SOCS3. Combined therapy reversed the TMZ resistance of LN428 cells, which could be related to the decreased levels of O6-methylguanine-DNA methyltransferase (MGMT) and STAT3	Wu et al. (2023)
Cisplatin + Resveratrol	Breast cancer Cisplatin-resistant MCF-7	RSV decreases cisplatin resistance and induces serine 20 (S20) phosphorylation on p53. Activate p53 target genes such as PUMA and Bax, restoring apoptosis. Bcl-2 decreased, and Bax protein increased	Hernandez-Valencia et al. (2018)