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. 2023 Nov 23;14:7643. doi: 10.1038/s41467-023-43418-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — SLC35D3 regulates obesity by interacting with the extracellular domain (ECD) of NOTCH1, which promotes NOTCH1 accumulation in the endoplasmic reticulum (ER) and inhibits NOTCH1 transport to the cell membrane, ultimately inhibiting NOTCH1 signaling. IngWAT, inguinal white adipose tissue.