TABLE 3.
Evaluation of the Intra-Day and Inter-Day Precision and Accuracy by the Proposed UPLC-MS/MS Method for Determination of lacosamide and ODL in various matrices (n = 5).
| Matrix | Analytes | Concentration (ng/mL) | Intra-Day | Inter-Day | ||
|---|---|---|---|---|---|---|
| Precision (RSD %) | Accuracy (RE %) | Precision (RSD %) | Accuracy (RE %) | |||
| Plasma | Lacosamide | 2 | 19.9 | −3.5 | 18.7 | 7.6 |
| 5 | 2.4 | −1.0 | 3.2 | 2.5 | ||
| 4,000 | 4.8 | 11.2 | 3.6 | 11.5 | ||
| 8,000 | 3.3 | −3.4 | 2.9 | 3.6 | ||
| ODL | 1 | 10.7 | −0.9 | 8.9 | 3.1 | |
| 2 | 9.2 | 2.0 | 6.9 | 0.1 | ||
| 400 | 2.6 | 2.0 | 3.7 | 0.7 | ||
| 800 | 6.4 | 5.5 | 5.3 | 5.0 | ||
| RLM | ODL | 80 | 12.3 | 0.0 | 11.6 | 3.0 |
| 200 | 4.5 | 3.5 | 6.0 | 5.0 | ||
| 16,000 | 3.7 | 5.5 | 7.6 | 11.8 | ||
| 32,000 | 6.7 | 2.5 | 6.4 | 4.3 | ||