TABLE 4.
Matrix effect and recovery rate of lacosamide and ODL in various matrices (n = 5).
| Matrix | Analytes | Concentration (ng/mL) | Recovery rate (%) | Matrix effect (%) | ||
|---|---|---|---|---|---|---|
| Mean ± SD | RSD% | Mean ± SD | RSD% | |||
| Plasma | Lacosamide | 5 | 104.8 ± 12.9 | 12.3 | 111.6 ± 4.5 | 4.0 |
| 4,000 | 110.4 ± 3.7 | 3.3 | 89.8 ± 5.8 | 6.5 | ||
| 8,000 | 99.0 ± 7.9 | 8.0 | 92.8 ± 7.7 | 8.3 | ||
| ODL | 2 | 92.5 ± 4.6 | 5.0 | 96.0 ± 3.6 | 3.8 | |
| 400 | 89.9 ± 5.0 | 5.6 | 95.7 ± 6.8 | 7.1 | ||
| 800 | 102.3 ± 3.6 | 3.6 | 112.5 ± 2.6 | 2.3 | ||
| RLM | ODL | 200 | 102.8 ± 5.6 | 5.4 | 99.6 ± 11.8 | 11.9 |
| 16,000 | 99.4 ± 4.6 | 4.6 | 109.2 ± 6.9 | 6.3 | ||
| 32,000 | 104.9 ± 8.2 | 7.8 | 105.3 ± 4.3 | 4.1 | ||