TABLE 5.
Stability Results of lacosamide and ODL in various matrices Under Different Conditions (n = 5).
| Matrix | Analytes | Concentration (ng/mL) | Room temperature (3 h) | 10°C (4 h) | Three freeze-thaw | 21 days | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) | |||
| Plasma | Lacosamide | 5 | 2.4 | 10.0 | 9.5 | −1.7 | 4.0 | 7.3 | 12.7 | 1.0 |
| 4,000 | 3.9 | 5.8 | 2.6 | 12.7 | 3.4 | 1.5 | 1.0 | −4.6 | ||
| 8,000 | 0.7 | −10.4 | 4.7 | −1.9 | 2.2 | −14.4 | 1.5 | −2.4 | ||
| ODL | 2 | 3.4 | 4.4 | 5.8 | −0.3 | 12.3 | −1.6 | 5.0 | 9.3 | |
| 400 | 4.1 | 0.0 | 2.3 | −7.4 | 4.6 | 1.6 | 2.5 | −5.1 | ||
| 800 | 4.4 | 0.6 | 2.8 | −7.4 | 2.9 | 4.1 | 5.8 | 0.0 | ||
| RLM | ODL | 200 | 9.5 | −4.3 | 5.2 | 9.9 | 4.8 | −10.4 | 10.9 | −9.7 |
| 16,000 | 2.9 | −0.2 | 3.2 | 10.4 | 2.8 | −0.9 | 3.5 | 1.1 | ||
| 32,000 | 1.6 | 1.9 | 7.3 | 2.6 | 3.4 | −1.0 | 2.2 | 3.9 | ||