TABLE 7.
The Pharmacokinetic Parameters of ODL in the Presence and Absence of nisoldipine (n = 6).
| Parameters | Lacosamide | Lacosamide + nisoldipine |
|---|---|---|
| AUC(0-t) (ng/mL*h) | 3422.11 ± 1,059.19 | 5,482.80 ± 807.91** |
| AUC(0-∞) (ng/mL*h) | 3423.38 ± 1,061.55 | 5,495.81 ± 817.99** |
| MRT(0-t) (h) | 6.01 ± 0.64 | 5.30 ± 0.39* |
| MRT(0-∞) (h) | 6.28 ± 0.74 | 5.44 ± 0.40* |
| t1/2z (h) | 3.26 ± 0.54 | 3.11 ± 0.21 |
| Tmax (h) | 3.50 ± 0.55 | 2.83 ± 0.75 |
| CLz/F (L/h/kg) | 3.11 ± 0.77 | 1.86 ± 0.32** |
| Vz/F (L/kg) | 14.99 ± 5.04 | 8.38 ± 1.71* |
| Cmax (ng/mL) | 558.05 ± 220.49 | 829.00 ± 128.67* |
AUC, area under the plasma concentration-time curve, t1/2z elimination half time, Tmax peak time, CLz/F plasma clearance, Cmax maximum blood concentration *p < 0.05, **p < 0.01, compared with the group A.