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. 2023 Nov 13;16(11):dmm050392. doi: 10.1242/dmm.050392

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Loxl1 deficiency in mice containing BL/6 causes enlargement of Schlemm's canal lumen. (A) Representative images of the outflow tract from sagittal semi-thin sections stained with Methylene Blue in BL/6 Loxl1^+/+, Loxl1^+/− and Loxl1^−/− mice. The Schlemm's canal (SC) perimeter is highlighted in yellow. Scale bar: 20 µm. (B) Quantitative analysis of SC perimeter revealed an enlarged SC in BL/6 Loxl1^+/− and Loxl1^−/− mice and in 50/50 Loxl1^−/− mice (n=4 mice, averaging three cross-sectional images/eye; **P<0.01). Boxes show the 25-75th percentiles, whiskers show the minimum and maximum, and the median is marked with a line. Ordinary one-way ANOVA followed by Dunnett's multiple comparisons test was used for statistical analysis.