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. 2023 Nov 13;16(11):dmm050392. doi: 10.1242/dmm.050392

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Young BL/6 Loxl1^−/− mice have dilated intrascleral veins. (A) Representative images of anterior chamber flat mounts immunostained with anti-CD31 antibody in BL/6 Loxl1^+/+, Loxl1^+/− and Loxl1^−/− mice. Yellow rectangles highlight the difference between distal vein diameter in Loxl1^+/+ versus Loxl1^−/− mice. A, artery; C, capillary; V, vein. Scale bar=100 µm. (B) Vessel diameter measurements for Loxl1^+/+, Loxl1^+/− and Loxl1^−/− mice from the three different studied backgrounds. Only BL/6 Loxl1^−/− mice displayed significantly dilated distal veins but not arteries or capillaries (n=4 eyes/mice, 4 quadrants/eye, *P<0.05). Boxes show the 25-75th percentiles, whiskers show the minimum and maximum, and the median is marked with a line. Ordinary one-way ANOVA followed by Dunnett's multiple comparisons test was used for statistical analysis.