Figure 4.

Microphotographs of stage-specific closure of the cortical plate defect in the study groups 14, 30, and 60 days after implantation (Masson’s trichrome × 40. Scale bar, 500 µm) (a–c) – HTBG group: (a) negative remodeling of the bone graft with lysis and resorption; single heterogeneous bundles of newly formed bone tissue are not integrated with the bone graft; (b) lysed bone graft is replaced by fibrous tissue, and the remaining fragments are integrated with newly formed bone beams; and (c) defect area is closed by newly formed bone tissue with foci of disorderly distribution of mature and immature bone matrix; (d–f) – HTBG with PRP (HTBG + PRP group): (d) positive remodeling of the bone graft with bone integration, remineralization, and circular formation of newly formed bone tissue, partial closure of the defect with newly formed bone beams; (e) the osteotomy site is closed with mature bone tissue with multiple wide bridge-like contacts between newly formed bone beams; and (f) the defect area is closed with mature bone tissue.