Table 4.

Clinical features reported in association with unexplained chronic throat symptoms

	Chronic inflammation—chronic laryngitis (CL)				Functional throat disorders (FTD)
Common pathophysiology	Chronic non-eosinophilic inflammation of the ADT			Chronic eosinophilic inflammation of the ADT	Abnormal sensory or motor function within the ADT or components, without clear organic disease correlates
Aetiology	GORD	Aeorsolised irritants	Voice behaviours	Aerosolised allergens	Aerodigestive sensory/reflex dysfunction	Aerodigestive motor dysfunction
Diagnoses	LPR, EER, RL	OL, WAL, WUACS, WAILS, OCS	VA, VTL, SD, MTD	LA, AL	ILS, LH, SLN, LD, CHS, ICC, RCC, GP	LD, MTD, FD, LHS, UESD, CPS, VCD, PVFM, STD
Reported symptoms
Cough	++	++	++	++	++	++
Dysphonia	++	++	+++	++	++	++
Dysphagia	+	+	+	+	++	+++
Globus	++	+	+	+	+++	++
Paraesthesia	++	++	++	++	+	+
Throat clearing	++	++	++	+++	++	++
Reported nasoendoscopic findings
Features of mucosal inflammation	++	++	++	++	++	++
Vocal cord dysfunction	+	+	++	+	++	++
Abnormal muscle tone or coordination	++	++	+++	++	+++	+++
Sensitive and specific clinical findings or biochemical markers	No	No	No	No	No	No

AL, allergic laryngitis; CHS, cough hypersensitivity syndromes; CPS, cricopharyngeal spasm; EER, extraesophageal reflux; FD, functional dysphonia; GORD, gastro-oesophageal reflux disease; GP, Globus pharyngeus; ICC, idiopathic chronic cough; ILS, irritable larynx syndrome; LA, laryngeal allergy; LD, laryngeal dysfunction; LH, laryngeal hypersensitivity; LHS, laryngeal hyperfunction syndromes; LPR, laryngopharyngeal reflux; MTD, muscle tension dysphonia; OCS, occupational cough syndrome; OL, occupational laryngitis; PVFM, Paradoxical vocal fold movement (excluding inducible laryngeal obstruction); RCC, refractory chronic cough; RL, reflux laryngitis; SD, Singers dysphonia; SLN, superior laryngeal nerve neuropathy; STD, supraglottic tension dysphonia ; UESD, upper oesophageal sphincter dysfunction; VA, vocal abuse; VCD, vocal cord dysfunction; VTL, vocal tension laryngitis; WAILS, Workplace associated irritable larynx syndrome OCS ; WAL, workplace-associated laryngitis; WUACS, Workplace upper airway cough syndrome .