Table 2.
Association between Klotho and hyperlipidemia among US adults in NHANES 2007–2016.
| Klotho (pg/mL) | Crude model | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Per SD increase | 0.87 (0.82, 0.93) | < 0.001 | 0.90 (0.85, 0.95) | < 0.001 | 0.91 (0.86, 0.97) | 0.005 |
| Quartiles | ||||||
| Q1 (≤ 654.33) | Reference | Reference | Reference | |||
| Q2 (654.33 – 801.40) | 1.00 (0.82, 1.22) | 0.971 | 1.03 (0.84, 1.25) | 0.787 | 1.05 (0.86, 1.28) | 0.614 |
| Q3 (801.40 – 990.93) | 0.80 (0.66, 0.96) | 0.019 | 0.82 (0.68, 1.00) | 0.049 | 0.84 (0.69, 1.02) | 0.083 |
| Q4 (> 993.93) | 0.65 (0.53, 0.80) | < 0.001 | 0.70 (0.57, 0.86) | 0.001 | 0.72 (0.58, 0.90) | 0.004 |
| p for trend | < 0.001 | < 0.001 | < 0.001 | |||
| Categories | ||||||
| Q1–Q3 (≤ 993.93) | Reference | Reference | Reference | |||
| Q4 (> 993.93) | 0.70 (0.60, 0.82) | < 0.001 | 0.74 (0.63, 0.87) | 0.001 | 0.75 (0.63, 0.89) | 0.002 |
Crude model: no cofounder.
Model 1: adjusted for age, gender, etc.
Model 2: adjusted for age, gender, race, education, alcohol intake, smoking status, body mass index, the family of poverty ratio, hypertension, diabetes, and CVD.
OR, odds ratio; CI, confidence interval.