Table 2.
Early time-point miRNA expression.
| (A) | ||||||
|---|---|---|---|---|---|---|
| miRNA | n | Survivors | n | Non-survivors | p value | AUC (95% CI) |
| miR-103 | 94 | 29.82 (0.35) | 89 | 29.76 (0.29) | 0.25 | |
| miR-122 | 94 | 31.80 (1.17) | 88 | 31.72 (1.40) | 0.67 | |
| miR-140 | 87 | 28.43 (0.47) | 84 | 28.42 (0.43) | 0.86 | |
| miR-149 | 26 | 26.97 (1.21) | 10 | 27.70 (1.05) | 0.10 | |
| miR-150 | 94 | 29.98 (0.48) | 88 | 30.20 (0.43) | 0.002* | 0.64 (0.55–0.72) |
| miR-16-2 | 56 | 27.83 (0.82) | 56 | 27.40 (0.92) | 0.01* | 0.65 (0.55–0.75) |
| miR-17 | 19 | 25.83 (0.88) | 25 | 25.79 (0.91) | 0.91 | |
| miR-191 | 55 | 29.49 (0.34) | 71 | 29.48 (0.32) | 0.97 | |
| miR-200b | 14 | 27.45 (0.81) | 9 | 27.14 (1.01) | 0.42 | |
| miR-20a | 5 | 26.81 (0.81) | 16 | 26.02 (0.97) | 0.12 | |
| miR-21 | 94 | 31.45 (0.77) | 89 | 31.42 (0.84) | 0.81 | |
| miR-221 | 93 | 28.89 (0.68) | 88 | 29.01 (0.64) | 0.24 | |
| miR-23a | 94 | 30.46 (0.21) | 89 | 30.47 (0.18) | 0.77 | |
| miR-24 | 94 | 30.11 (0.65) | 89 | 30.09 (0.68) | 0.86 | |
| miR-26 | 94 | 29.56 (0.28) | 89 | 29.61 (0.26) | 0.22 | |
| miR-27a | 94 | 29.16 (0.47) | 89 | 29.32 (0.50) | 0.03 | 0.60 (0.52–0.68) |
| miR-29b | 33 | 26.28 (1.69) | 36 | 25.32 (0.75) | 0.003* | 0.72 (0.60–0.84) |
| miR-30a | 94 | 29.35 (0.84) | 89 | 29.45 (0.84) | 0.42 | |
| miR-330 | 16 | 26.71 (1.25) | 22 | 26.19 (1.39) | 0.25 | |
| miR-4270 | 50 | 27.24 (1.23) | 38 | 26.94 (1.28) | 0.28 | |
| miR-503 | 14 | 26.47 (1.00) | 13 | 26.23 (1.21) | 0.49 | |
| miR-663 | 53 | 27.23 (1.29) | 47 | 26.91 (1.10) | 0.19 | |
| (B) | ||
|---|---|---|
| miRNA | OR (95% CI) | p value |
| miR-149 | 0.33 (0.15–0.71) | 0.006* |
| miR-16-2 | 1.15 (0.63–2.12) | 0.65 |
| miR-17 | 1.54 (0.80–3.11) | 0.23 |
| miR-191 | 2.80 (1.46–5.49) | 0.002* |
| miR-200b | 0.64 (0.27–1.59) | 0.38 |
| miR-20a | 3.90 (1.47–10.02) | 0.01* |
| miR-29 | 1.26 (0.68–2.32) | 0.54 |
| miR-330 | 1.60 (0.77–3.29) | 0.21 |
| miR-4270 | 0.66 (0.37–1.16) | 0.18 |
| miR-503 | 0.98 (0.43–2.18) | >0.9999 |
| miR-663 | 0.87 (0.49–1.54) | 0.66 |
(A) Results of t tests between survivors and non-survivors. Results given as mean (SD). If p values <0.05, AUC was calculated. (B) For miRNA detected in <85% of samples at the early time-point, reanalysis was performed after converting results to either detected (1) or undetected (0) using Fisher’s exact test – OR for mortality. Statistical significance set as per Benjamini-Hochberg procedure with a false discovery rate of 0.05 (*p <0.026). miR/miRNA, microRNA; OR, odds ratio.