Table 4.

The diagnostic accuracy of the four tests for the diagnosis of pulmonary tuberculosis.

Test	Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)
AFB smear	27.1 (95% CI: 15.3-41.8)	90.9 (95% CI: 58.7-99.8)	92.9 (95% CI: 66.1-99.8)	22.2 (95% CI: 11.2-37.1)
M.tb culture	39.6 (95% CI: 25.8-54.7)	100.0 (95% CI: 69.2-100.0)	100.0 (95% CI: 82.4-100.0)	25.6 (95% CI: 13.0-42.1)
Xpert MTB/RIF	56.2 (95% CI: 41.2-70.5)	100.0 (95% CI: 69.2-100.0)	100.0 (95% CI: 87.2-100.0)	32.3 (95% CI: 16.7-51.4)
Targeted nanopore sequencing	89.6 (95% CI: 77.3-96.5)	100.0 (95% CI: 69.2-100.0)	100.0 (95% CI: 91.8-100.0)	66.7 (95% CI: 38.4-88.2)

AFB, acid-fast bacilli; CI, confidence interval; M.tb, Mycobacterium tuberculosis; NPV, negative predictive value; PPV, positive predictive value.