Table 2.
miRNA with assigned function in MSCs
miRNA | Effect in MSC | MSC source | Target(s) | Ref. |
---|---|---|---|---|
let-7 | Inhibits adipogenesis and migration of cell lines | h-BM | IL6 | [18] |
miR-10a | Promotes differentiation and inhibits senescence | h-BM | KLF4 | [19] |
miR-10b | Promotes cell migrationa | m-BM | n.d. | [20] |
miR-16 | Promotes G1 arrest and myogenesisa | h-BM | n.d. | [21] |
Inhibits proliferation and angiogenic potential | h-decidua MSC | CCNE1 | [22] | |
miR-17 | Promotes osteogenesis | h-PO | SMURF1 | [16] |
miR-20a | Promotes osteogenesis | h-BM | PPARγ, BAMBI, CRIM1 | [17] |
miR-21 | Promotes survival in hypoxia/serum starvation | r-BM | n.d. | [23] |
Promotes osteogenesis and adipogenesis | h-AT | SPRY2 | [24] | |
Promotes osteogenesis | h-BM | SPRY1/2 | [25] | |
Promotes adipogenesis | h-AT | TGFBR2 | [26] | |
Inhibits proliferation | h-AT | STAT3 | [27] | |
miR-23a | Promotes survival in hypoxia/serum starvation | r-BM | n.d. | [23] |
Inhibits osteogenesis | m-cell line | RUNX2, SATB2 | [28] | |
miR-23b | Promotes chondrogenesisa | h-BM | PRKACB | [29] |
miR-24 | Inhibits osteogenesis | m-cell line | SATB2 | [28] |
Promotes adipogenesis | m-cell line | n.d. | [30] | |
miR-26a | Inhibits osteogenesis | h-AT | SMAD1 | [31] |
miR-27a | Inhibits osteogenesis | h-BM, m-cell line | SATB2 | [28, 32] |
Inhibits adipogenesisa | m-cell line | PPARγ | [33] | |
miR-27b | Inhibits adipogenesis | h-AT, m-cell line | PPARγ, CEBPα | [34, 35] |
Promotes immune regulation | r-AT | SDF-1α | [36] | |
Inhibits cell migrationa | m-BM | SDF-1α | [37] | |
miR-29a | Promotes osteogenesis | h-BM | DKK1, KREMEN2, SFRP2 | [38] |
miR-30 | Promotes adipogenesis | h-AT | RUNX2 | [13] |
Inhibits osteogenesis | m-BM | SMAD1 | [39] | |
miR-31 | Inhibits adipogenesis | m-cell line | CEBP/A | [30] |
Inhibits osteogenesis | h-BM | OSTERIX, n.d. | [40, 41] | |
miR-32 | Reverses high glucose- cell cycle arresta | r-BM | n.d. | [42] |
miR-100 | Inhibits osteogenesis | h-AT | BMPR2 | [43] |
miR-107 | Protects against anoxia | r-BM | PDCD10 | [44] |
miR-124 | Inhibits cardiomyogenesis | r-BM | STAT3 | [45] |
Inhibits proliferationa | h-BM | n.d. | [46] | |
miR-125b | Inhibits osteogenesis and proliferation | m-BM | n.d. | [47] |
Promotes survival | h-BM | P53 | [48] | |
miR-126 | Promotes angiogenesisa | m-BM | n.d. | [49] |
Promotes endothelial differentiationa | m-BM | n.d. | [50] | |
miR-130a | Induces substance P productionb | h-BM | TAC1 | [51] |
miR-133 | Inhibits osteogenesisa | m-cell line | RUNX2 | [52] |
Promotes proliferation | r-BM | n.d. | [53] | |
miR-135 | Inhibits osteogenesis | m-cell line | SMAD5 | [52] |
miR-138 | Inhibits adipogenesisa | h-AT | EID1 | [54] |
Inhibits osteogenesis | h-BM | FAK | [55] | |
miR-140 | Promotes chondrogenesis | h-BM, m-BM, m-cell line | ADAMTS-5, HDAC4 | [56–58] |
miR-141 | Inhibits osteogenesis | m-cell line | DLX5 | [59] |
miR-142-3p | Promotes osteogenesis | h-cell line | APC | [60] |
miR-143 | Promotes adipogenesis | preadipocyte | n.d. | [61] |
Promotes proliferation | r-BM | ERK5 | [62] | |
miR-145 | Inhibits chondrogenesis | m-BM | SOX9 | [63, 64] |
miR-146a-5p | Inhibits immune regulation | m-BM | PTGES2 | [65] |
Promotes TNF-α-mediated IL-8 | h-BM | n.d. | [66] | |
Promotes survival against anoxia | r-BM | FAS | [67] | |
Inhibits migration and promotes proliferation | h-BM and h-UC | SDF-1α, | [14] | |
miR-148b | Promotes osteogenesis | h-BM | n.d. | [32] |
miR-155 | Inhibits adipogenesisa | h-cell line | n.d. | [68] |
Inhibits immune regulation | m-BM | TAB2 | [69] | |
miR-181 | Inhibits immune suppression | h-BM | TGFBR1, TGFBRAP1 | [70] |
miR-182 | Inhibits osteogenesis | m-cell line | FOXO1 | [71] |
miR-193 | Promotes proliferation | r-BM | ING5 | [53] |
miR-194 | Inhibits chondrogenesis | h-AT | SOX5 | [72] |
miR-196a | Promotes osteogenesis and inhibits proliferation | h-AT | HOXC8 | [73] |
miR-199a* | Inhibits chondrogenesis | m-cell line | SMAD1 | [74] |
miR-200a | Inhibits osteogenesis | m-cell line | DLX5 | [59] |
miR-204/211 | Inhibits osteogenesis | h-BM | RUNX2 | [75] |
miR-206 | Induces substance P productionb | h-BM | TAC1 | [51] |
Inhibits osteogenesis | m-cell line | CX43 | [76] | |
Promote myogenesis | m-cell line | CX43 | [125] | |
miR-210 | Promotes osteogenesis | m-cell line | ACVR1B | [77] |
Promotes survival in hypoxia/serum starvation | r-BM | CASP8AP2 | [23, 44] | |
Promotes proliferation | h-AT | PTPN2 | [78] | |
miR-221/222 | Inhibits adipogenesisa | h-cell line | n.d. | [68] |
miR-302 | Induces substance P productionb | h-BM | TAC1 | [51] |
miR-335 | Inhibits proliferation, migration and differentiation | h-BM | RUNX2 | [79] |
miR-369-5p | Inhibits adipogenesis and proliferation | h-BM | FABP4 | [80] |
miR-371 | Promotes adipogenesis and inhibits proliferation | h-BM | n.d. | [80] |
miR-449a | Inhibits chondrogenesisa | h-BM | LEF-1 | [81] |
miR-489 | Inhibits osteogenesis | h-BM | n.d. | [32] |
miR-499 | Inhibits proliferation | h-BM | n.d. | [80] |
miR-503 | Promotes survival in hypoxia/serum starvation | r-BM | n.d. | [23] |
miR-541 | Inhibits osteogenesis | h-BM | n.d. | [82] |
miR-574-3p | Inhibits chondrogenesis | h-BM | RXRα | [83] |
miR-705 | Inhibits osteogenesis and promote adipogenesis | m-BM | HOXA10 | [84] |
miR-886-3p | Inhibits migration | h-BM | SDF-1α | [85] |
miR-2861 | Promotes osteogenesis | m-BM | HDAC5 | [79] |
miR-3077-5p | Inhibits osteogenesis and promote adipogenesis | m-BM | RUNX2 | [84] |
Effect was only confirmed by over-expression of the miRNA, not by silencing the endogenous miRNA.
In MSC-derived neuronal cells.
Abbreviations: AT, adipose tissue-derived; BM, bone marrow-derived; h, human; miRNAs, microRNAs; MSCs, mesenchymal stromal cells; m, mouse; n.d., not determined; PO, periodontal ligament; r, rat; UC, umbilical cord.