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. Author manuscript; available in PMC: 2023 Nov 24.
Published in final edited form as: Stem Cells. 2014 May;32(5):1074–1082. doi: 10.1002/stem.1623

Table 2.

miRNA with assigned function in MSCs

miRNA Effect in MSC MSC source Target(s) Ref.
let-7 Inhibits adipogenesis and migration of cell lines h-BM IL6 [18]
miR-10a Promotes differentiation and inhibits senescence h-BM KLF4 [19]
miR-10b Promotes cell migrationa m-BM n.d. [20]
miR-16 Promotes G1 arrest and myogenesisa h-BM n.d. [21]
Inhibits proliferation and angiogenic potential h-decidua MSC CCNE1 [22]
miR-17 Promotes osteogenesis h-PO SMURF1 [16]
miR-20a Promotes osteogenesis h-BM PPARγ, BAMBI, CRIM1 [17]
miR-21 Promotes survival in hypoxia/serum starvation r-BM n.d. [23]
Promotes osteogenesis and adipogenesis h-AT SPRY2 [24]
Promotes osteogenesis h-BM SPRY1/2 [25]
Promotes adipogenesis h-AT TGFBR2 [26]
Inhibits proliferation h-AT STAT3 [27]
miR-23a Promotes survival in hypoxia/serum starvation r-BM n.d. [23]
Inhibits osteogenesis m-cell line RUNX2, SATB2 [28]
miR-23b Promotes chondrogenesisa h-BM PRKACB [29]
miR-24 Inhibits osteogenesis m-cell line SATB2 [28]
Promotes adipogenesis m-cell line n.d. [30]
miR-26a Inhibits osteogenesis h-AT SMAD1 [31]
miR-27a Inhibits osteogenesis h-BM, m-cell line SATB2 [28, 32]
Inhibits adipogenesisa m-cell line PPARγ [33]
miR-27b Inhibits adipogenesis h-AT, m-cell line PPARγ, CEBPα [34, 35]
Promotes immune regulation r-AT SDF-1α [36]
Inhibits cell migrationa m-BM SDF-1α [37]
miR-29a Promotes osteogenesis h-BM DKK1, KREMEN2, SFRP2 [38]
miR-30 Promotes adipogenesis h-AT RUNX2 [13]
Inhibits osteogenesis m-BM SMAD1 [39]
miR-31 Inhibits adipogenesis m-cell line CEBP/A [30]
Inhibits osteogenesis h-BM OSTERIX, n.d. [40, 41]
miR-32 Reverses high glucose- cell cycle arresta r-BM n.d. [42]
miR-100 Inhibits osteogenesis h-AT BMPR2 [43]
miR-107 Protects against anoxia r-BM PDCD10 [44]
miR-124 Inhibits cardiomyogenesis r-BM STAT3 [45]
Inhibits proliferationa h-BM n.d. [46]
miR-125b Inhibits osteogenesis and proliferation m-BM n.d. [47]
Promotes survival h-BM P53 [48]
miR-126 Promotes angiogenesisa m-BM n.d. [49]
Promotes endothelial differentiationa m-BM n.d. [50]
miR-130a Induces substance P productionb h-BM TAC1 [51]
miR-133 Inhibits osteogenesisa m-cell line RUNX2 [52]
Promotes proliferation r-BM n.d. [53]
miR-135 Inhibits osteogenesis m-cell line SMAD5 [52]
miR-138 Inhibits adipogenesisa h-AT EID1 [54]
Inhibits osteogenesis h-BM FAK [55]
miR-140 Promotes chondrogenesis h-BM, m-BM, m-cell line ADAMTS-5, HDAC4 [5658]
miR-141 Inhibits osteogenesis m-cell line DLX5 [59]
miR-142-3p Promotes osteogenesis h-cell line APC [60]
miR-143 Promotes adipogenesis preadipocyte n.d. [61]
Promotes proliferation r-BM ERK5 [62]
miR-145 Inhibits chondrogenesis m-BM SOX9 [63, 64]
miR-146a-5p Inhibits immune regulation m-BM PTGES2 [65]
Promotes TNF-α-mediated IL-8 h-BM n.d. [66]
Promotes survival against anoxia r-BM FAS [67]
Inhibits migration and promotes proliferation h-BM and h-UC SDF-1α, [14]
miR-148b Promotes osteogenesis h-BM n.d. [32]
miR-155 Inhibits adipogenesisa h-cell line n.d. [68]
Inhibits immune regulation m-BM TAB2 [69]
miR-181 Inhibits immune suppression h-BM TGFBR1, TGFBRAP1 [70]
miR-182 Inhibits osteogenesis m-cell line FOXO1 [71]
miR-193 Promotes proliferation r-BM ING5 [53]
miR-194 Inhibits chondrogenesis h-AT SOX5 [72]
miR-196a Promotes osteogenesis and inhibits proliferation h-AT HOXC8 [73]
miR-199a* Inhibits chondrogenesis m-cell line SMAD1 [74]
miR-200a Inhibits osteogenesis m-cell line DLX5 [59]
miR-204/211 Inhibits osteogenesis h-BM RUNX2 [75]
miR-206 Induces substance P productionb h-BM TAC1 [51]
Inhibits osteogenesis m-cell line CX43 [76]
Promote myogenesis m-cell line CX43 [125]
miR-210 Promotes osteogenesis m-cell line ACVR1B [77]
Promotes survival in hypoxia/serum starvation r-BM CASP8AP2 [23, 44]
Promotes proliferation h-AT PTPN2 [78]
miR-221/222 Inhibits adipogenesisa h-cell line n.d. [68]
miR-302 Induces substance P productionb h-BM TAC1 [51]
miR-335 Inhibits proliferation, migration and differentiation h-BM RUNX2 [79]
miR-369-5p Inhibits adipogenesis and proliferation h-BM FABP4 [80]
miR-371 Promotes adipogenesis and inhibits proliferation h-BM n.d. [80]
miR-449a Inhibits chondrogenesisa h-BM LEF-1 [81]
miR-489 Inhibits osteogenesis h-BM n.d. [32]
miR-499 Inhibits proliferation h-BM n.d. [80]
miR-503 Promotes survival in hypoxia/serum starvation r-BM n.d. [23]
miR-541 Inhibits osteogenesis h-BM n.d. [82]
miR-574-3p Inhibits chondrogenesis h-BM RXRα [83]
miR-705 Inhibits osteogenesis and promote adipogenesis m-BM HOXA10 [84]
miR-886-3p Inhibits migration h-BM SDF-1α [85]
miR-2861 Promotes osteogenesis m-BM HDAC5 [79]
miR-3077-5p Inhibits osteogenesis and promote adipogenesis m-BM RUNX2 [84]
a

Effect was only confirmed by over-expression of the miRNA, not by silencing the endogenous miRNA.

b

In MSC-derived neuronal cells.

Abbreviations: AT, adipose tissue-derived; BM, bone marrow-derived; h, human; miRNAs, microRNAs; MSCs, mesenchymal stromal cells; m, mouse; n.d., not determined; PO, periodontal ligament; r, rat; UC, umbilical cord.

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