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. 2023 Oct 28;13(11):1587. doi: 10.3390/biom13111587

Figure 2.

Figure 2

Structure and sequence of KRAS4B. (A) Crystal structure of wild-type (WT) KRAS with GDP bound (PDB ID: 4obe). The C-terminal HVR is not present in the structure. (B) 2D depiction of the secondary structure of KRAS. Disordered regions are indicated by lines. (C) Sequence of KRAS4B. The most common mutation hotspots are indicated by arrows. Selected structural regions in all (A–C) are highlighted with the following color scheme: P-loop (residues 10–14), orange; switch-I (residues 30–40), red; switch-II (residues 58–72), blue; HVR (residues 167–188), green. Adapted from [56].