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. 2023 Oct 26;12(11):1914. doi: 10.3390/antiox12111914

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ZYAN1 alleviates the morphology damage in RD model at P28. (A) Retinal structure in the RD + ZYAN1 group was intact. The ONL in RD + ZYAN1 group was thicker than in RD group. (B) In OCT examination, the boundary between retinal layers was clear in the RD + ZYAN1 group, and the retinal thickness was significantly larger than in RD group. The scale of retinal lesions reduced prominently after ZYAN1 treatment. (C) Immunofluorescence staining of rhodopsin showed that the rod photoreceptors in the RD + ZYAN1 group were effectively preserved. The IS/OS length was significantly larger than in RD group (**** p < 0.0001 for differences compared with normal control group; ^### p < 0.001, ^#### p < 0.0001 for differences compared with RD + ZYAN1 group, n = 6).