Table 3.
Univariable associations between patient characteristics and BKPyV.
| N | n (%) with BKPyV | Hazard Ratio (95% Confidence Interval) |
p-Value | |
|---|---|---|---|---|
| Overall | 102 | 18 (17.6) | -- | |
| Age, 5-year increase | -- | -- | 1.04 (0.81–1.36) | 0.77 |
| Age | ||||
| <65 | 54 | 11 (20.4) | 1 (ref) | 0.44 |
| ≥65 | 48 | 7 (14.6) | 0.69 (0.26–1.76) | |
| Race/ethnicity | ||||
| African American | 67 | 8 (11.9) | 1 (ref) | 0.03 |
| White | 27 | 6 (22.2) | 2.05 (0.67–5.91) | |
| Other | 8 | 4 (50.0) | 4.43 (1.18–14.1) | |
| Cause of ESRD | ||||
| Diabetes | 46 | 10 (21.7) | 1 (ref) | 0.26 |
| Hypertension | 26 | 2 (7.7) | 0.30 (0.05–1.16) | |
| Other | 30 | 6 (20.0) | 0.91 (0.31–2.46) | |
| Transplant type | ||||
| DDKT | 71 | 12 (16.9) | 1 (ref) | |
| DCD | 28 | 6 (21.4) | 1.21 (0.46–3.16) | 0.88 |
| LKT | 3 | 0 (0.0) | -- | |
| History of hepatitis C | ||||
| No | 73 | 11 (15.1) | 1 (ref) | 0.32 |
| Yes | 29 | 7 (24.1) | 1.62 (0.59–4.13) | |
| History of hepatitis B | ||||
| No | 93 | 17 (18.3) | 1 (ref) | 0.82 |
| Yes | 9 | 1 (11.1) | 0.83 (0.09–3.27) | |
| Immunologic risk | ||||
| No | 92 | 13 (14.1) | 1 (ref) | 0.004 |
| Yes | 10 | 5 (50.0) | 4.13 (1.32–11.0) | |
| CMV risk | ||||
| 1 | 6 | 1 (16.7) | 1 (ref) | 0.96 |
| 2 | 48 | 9 (18.8) | 0.99 (0.19–18.2) | |
| 3 | 48 | 8 (16.7) | 0.86 (0.16–15.9) | |
| cPRA > 0 | ||||
| 0 | 94 | 14 (14.9) | 1 (ref) | 0.005 |
| >0 | 8 | 4 (50.0) | 4.34 (1.23–12.14) | |
| Donor age, 5-year increase | -- | -- | 0.94 (0.78–1.13) | 0.53 |
| Donor age | ||||
| <40 | 45 | 9 (20.0) | 1 (ref) | 0.62 |
| ≥40 | 57 | 9 (15.8) | 0.79 (0.31–2.03) | |
| KDPI, 10-point increase | -- | -- | 1.03 (0.85–1.26) | 0.75 |
| KDPI | ||||
| <50 | 45 | 8 (17.8) | 1 (ref) | 0.94 |
| ≥50 | 54 | 10 (18.5) | 1.04 (0.41–2.71) | |
| Induction | ||||
| <4 mg/kg | 31 | 5 (16.1) | 1 (ref) | 0.97 |
| >4 mg/kg | 38 | 7 (18.4) | 1.03 (0.33–3.50) | |
| Basiliximab | 33 | 6 (18.2) | 1.14 (0.34–3.97) | |
| Delayed graft function | ||||
| No | 71 | 11 (15.5) | 1 (ref) | 0.39 |
| Yes | 31 | 7 (22.6) | 1.51 (0.56–3.84) |