Table 3.

Analyses of the association of use of metformin with risk of developing severe dementia.

	HR (95% CI)	p Value
Multivariable Adjusted Analysis a
No metformin use	1 [Reference]	1 [Reference]
Metformin use	0.96 (0.63–1.46)	=0.85
Unadjusted Analysis
No metformin use	1 [Reference]	1 [Reference]
Metformin use	0.89 (0.59–1.33)	=0.56

Abbreviations: HR, hazard ratio; CI, confidence interval. ^a Adjusted for age; gender; education level; baseline MMSE score; status of APOE ε4 carrier; diagnosis of hypertension; congestive heart failure; atrial fibrillation; use of dementia medication, antihypertensive medication, and antidepressants.