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. 2023 Oct 30;11(11):2935. doi: 10.3390/biomedicines11112935

Table 4.

Cox proportional hazard regression analysis for APOE ε4 carrier and non-carriers.

APOE ε4 Carrier (366) APOE ε4 Non-Carrier (676)
Users
(n = 190)
Non-Users
(n = 176)
Users vs. Non-Users Users
(n = 331)
Non-Users
(n = 345)
Users vs. Non-Users
Events Event Rate Events Event Rate Adjusted HR a (95%CI) Events Event Rate Events Event Rate Adjusted
HR a (95%CI)
Severe dementia 20 10.5% 22 12.5% 0.92 (0.48–1.77), p = 0.80 28 8.5% 23 6.7% 1.13 (0.64–2.01), p = 0.67

Abbreviations: HR, hazard ratio; CI, confidence interval. a Adjusted for age; gender; education level; baseline MMSE score; status of APOE ε4 carrier; diagnosis of hypertension; congestive heart failure; atrial fibrillation; use of dementia medication, antihypertensive medication, and antidepressants.