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. 2023 Nov 7;12(11):1978. doi: 10.3390/antiox12111978
PH Pulmonary hypertension
Nrf2 Nuclear factor erythroid 2-related factor 2
VSMC vascular smooth muscle cell
PAEC pulmonary arterial endothelial cell
PASMC pulmonary arterial smooth muscle cell
PAH Pulmonary arterial hypertension
ROS reactive oxygen species
NOS nitric oxide synthase
NADPH nicotinamide adenine dinucleotide phosphate
SOD superoxide dismutase
ET-1 endothelin-1
PGI2 prostacyclin
EC endothelial cell
SMC smooth muscle cell
EMT epithelial-mesenchymal transition
NO nitric oxide
EDHF endothelium-derived hyperpolarizing factor
VGCC Voltagegated calcium channels
MCT monocrotaline
NHE Na+/H+ exchanger
ARE antioxidant response element
EpRE electrophile response element
GST glutathione S-transferase
GCL glutamate-cysteine ligase
GPx glutathione peroxidase
TXNRD thioredoxin reductase
TXN thioredoxin
GSH glutathione
sMAF small musculoaponeurotic fibrosarcoma
cAMP cyclic adenosine monophosphate
β-TrCP β-transducin repeat-containing protein
RXR-α retinoic X receptor alpha
Keap1 Kelch-like ECH-associated protein 1
BTB Bric-a-Brac domain
IVR intervening region
LncRNA long non-coding RNA
RVH right ventricular hypertrophy
SFN sulforaphane
KCNK3 potassium channel subfamily K member 3
Ipt Iptakalim
PPARγ peroxisome proliferator gamma
DMF Dimethyl Fumarate
RVSP right ventricular systolic pressure
SuHx SU5416 and 10% hypoxia
GCL glutamate-cysteine ligase
RV/(LV+S) right ventricular hypertrophy index