Table 1.

Anamnestic details and obstetric outcomes comparing women with high levels of sFlt-1 versus low levels of sFlt-1 [Mean; standard deviation—SD; n; (%)].

Multiple Pregnancies—n = 39	High Levels of sFlt-1	Low Levels of sFlt-1	p Value
	sFlt-1 ≥ 15,802 pg/mL	sFlt-1 < 15,802 pg/mL
	n = 15 (38)	n = 24 (62)
Types
DD twins	12 (80)	22 (92)	0.354
MD twins	1 (7)	1 (4)	1.000
MM twins	1 (7)	0	0.384
Triplets	1 (7)	1 (4)	1.000
Maternal anamnestic characteristics
Age (years)	37 ± 5	35 ± 6	0.136
Nulliparous	11 (73)	19 (79)	0.711
Obesity (BMI > 30 kg/m2)	3 (20)	5 (21)	1.000
Diabetes/GDM	4 (27)	4 (17)	0.685
Chronic hypertension	2 (13)	0	0.141
sFlt-1
GA at blood test (weeks.days)	33.6 ± 3.5	35.4 ± 1.3	0.136
Latency time between blood test and delivery (days)	3 ± 3	7 ± 4	0.007
Pregnancy complications at blood test
HD	9 (60)	9 (38)	0.202
HD + FGR	3 (20)	6 (25)	1.000
FGR	3 (20)	9 (38)	0.305
GA at 1st hospitalization for HD/FGR (weeks.days)	32.5 ± 4.2	34.6 ± 1.3	0.126
GA at delivery (weeks.days)	34.2 ± 3.5	36.4 ± 1.0	0.060
Adverse outcomes
Birth < 34 weeks	4 (27)	0	0.016
Urgent cesarean section for HD/FGR	4 (27)	0	0.016
HELLP syndrome	2 (13)	0	0.141
ICU admission for HD complications	2 (13)	0	0.141
Antihypertensive therapy before delivery	7 (47)	1 (4)	0.002
Antihypertensive therapy at postpartum discharge	7 (47)	4 (17)	0.068

Legend: DD twins—dichorionic–diamniotic twins, MD twins—monochorionic–diamniotic twins, MM twins—monochorionic–monoamniotic twins, BMI—body mass index, GDM—gestational diabetes mellitus, GA—gestational age, HD—hypertensive disorders: preE, gestational hypertension, uncontrolled chronic hypertension, FGR—fetal growth restriction, HELLP syndrome—hemolysis, elevated liver enzymes, and low platelets syndrome, ICU—intensive care unit.