Figure 3.

Scatterplots of MR tests assessing the effects of gamma-glutamyl transferase on stroke. (A) Before removing SNPs related to confounding factors; (B) After removing SNPs related to confounding factors. Alcohol consumption, atrial fibrillation, and body mass index were considered as confounding factors. Light blue, dark blue, light green, and dark green regression lines represent the IVW, MR–Egger, MR–Egger (SIMEX), and weighted median estimates, respectively. Red dots indicate outliers found in the MR–PRESSO analysis. SNP, single-nucleotide polymorphism; GGT, gamma-glutamyl transferase; IVW, inverse-variance weighted; SIMEX, simulation extrapolation; MR, Mendelian randomization; MR–PRESSO, MR-pleiotropy residual sum and outlier test.