Table 3.
Multivariable IVW MR results of gamma-glutamyl transferase, alcohol consumption, atrial fibrillation, and body mass index on stroke and stroke subtypes.
| Stroke | Cardioembolic Stroke | Small Vessel Stroke | Large Artery Stroke | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MR Exposures | N | OR (95% CI) | p-Value | N | OR (95% CI) | p-Value | N | OR (95% CI) | p-Value | N | OR (95% CI) | p-Value |
| Serum gamma-glutamyl transferase | 409 | 1.30 (1.07, 1.60) | 0.010 | 397 | 1.15 (0.75, 1.77) | 0.531 | 384 | 1.79 (1.01, 3.16) | 0.046 | 384 | 1.94 (1.06, 3.56) | 0.032 |
| Alcohol consumption | 409 | 0.96 (0.90, 1.03) | 0.238 | 397 | 0.97 (0.84, 1.12) | 0.665 | 384 | 0.88 (0.73, 1.07) | 0.205 | 384 | 0.96 (0.78, 1.17) | 0.663 |
| Atrial fibrillation | 409 | 1.13 (1.09, 1.17) | <0.001 | 397 | 1.86 (1.73, 2.01) | <0.001 | 384 | 1.02 (0.93, 1.13) | 0.630 | 384 | 1.03 (0.92, 1.14) | 0.616 |
| Body mass index | 409 | 1.10 (1.02, 1.18) | 0.009 | 397 | 0.97 (0.83, 1.13) | 0.677 | 384 | 1.16 (0.95, 1.41) | 0.149 | 384 | 1.20 (0.97, 1.48) | 0.100 |
N, number of instruments; IVW, inverse-variance weight; MR, Mendelian randomization; OR, odds ratio; CI, confidence interval.