Figure 3.

Molecular mechanism of pyroptosis in the form of lytic programmed cell death is characterized by its highly inflammatory nature and is most frequently observed following intracellular pathogen infections. TLR: Toll-like receptor, TRIF: TIR-domain-containing adapter-inducing interferon-β, MYD88: myeloid differentiation primary response protein 88, TAk1: transforming growth factor (TGF)-β-activated kinase 1, TAB: TAK1-binding protein, IKK: nuclear factor kappa-B kinase, NF-κB: nuclear factor kappa B, NLRP3: nod-like receptor family pyrin domain containing 3, AIM2: absent in melanoma-2, NLRC4: nod-like receptor family CARD domain containing 4, and NALP1: nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 1. Purple ellipse indicted a complex.