Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Top drug candidates for upregulated and downregulated hub genes.
| Expression | Genes | Drug | Known Mechanism | Tau | FDR |
|---|---|---|---|---|---|
| Upregulated | PSMA3, PSMA5, CCT4, CCT2, PSMD1, CDK1, ESR1, SMAD3, PTK2, UBC, HSP90AA1, ATP5A1, NEDD8, PSMA3, SNRPE, SNRPD2, SNRPD3, CYC1 | Dorzolamide | Carbonic anhydrase inhibitor | −99.75 | 2.78 × 10−3 |
| Downregulated | CREBBP, EGFR, PTPN11, H2AFX, RXRA, EP300, JUN, EGFR, MED1, FOXO1, SMAD4, RXRA | Oxybuprocaine | Local anesthetic | −99.76 | 3.64 × 10−3 |
