Table A8.

The top 10 hub genes in the midnight-blue module were identified through PPI networks and their functions obtained from the GeneCards database (www.genecards.org (accessed 23 August 2023)) [103].

Symbol	Function
EP300	Transcription regulation, non-histone protein acetylation
JUN	Transcriptional activation in certain cancer pathways
EGFR	G protein-coupled receptor signaling is involved in learning and memory functions
MED1	Transcription of RNA polymerase II-dependent genes
FOXO1	Metabolic homeostasis, oxidative stress response, redox balance, DNA repair in beta-cells, autophagic cell death
KAT2A	Promotes transcriptional activation and plays a role in chromatin remodeling
SMAD4	TGF-beta signal transduction, transcription regulation, tumor suppression,
RXRA	Regulates gene expression by binding to retinoic acid response elements
BCL2L11	Cell death regulation
PTK2	Cell migration/adhesion, cytoskeleton reorganization, nervous system development, apoptosis, signal transduction, and P53/TP53 activity regulation