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. 2023 Oct 28;11(11):2915. doi: 10.3390/biomedicines11112915

Figure 1.

Figure 1

Schematic representation of CLCA2 protein structure. The locations of the TVE20, Myc tag, and Flag tag epitopes relative to the cleavage site (scissors) are indicated. ss, signal sequence; CLCA-N, metalloprotease domain; VWA, von Willebrand A domain; bsr, beta sheet domain; fn3, fibronectin-3-like domain; tms, transmembrane segment; C-tail, cytoplasmic tail. Relative location of the zinc-binding HEWAHL motif is indicated; asterisk, site of the E165Q substitution. Lower, apparent sizes of precursor and cleavage products.