Table 1.
Phenotypic antibiogram of clinical strain P. aeruginosa, showing an OprD loss of function/downregulation.
| P. aeruginosa | Blood Culture | |
|---|---|---|
| Antibiotic | MIC | SIR * |
| Meropenem/Vaborbactam | =4/4 | S |
| Imipenem/Relebactam | =2/2 | S |
| Amikacin | =8.0 | S |
| Cefepime | =4.0 | I |
| Ceftazidime | =4.0 | I |
| Ceftazidime/Avibactam | =2.0 | S |
| Ceftolozane/Tazobactam | =1.0 | S |
| Ciprofloxacin | =0.125 | I |
| Colistin | =1.0 | S |
| Imipenem | >8 | R |
| Meropenem | =4 | I |
| Piperacillin/Tazobactam | =8.0 | I |
MIC = minimum inhibitory concentration; SIR = Susceptible (S), Susceptible, Iincreased Eexposure (I), and Resistant (R). * Breakpoint sec. Clinical breakpoints (v 13.1) [44]. Comment: phenotype resistance to imipenem, increased MIC of meropenem, and main-tained susceptibility to others common β-lactams. The phenotype could be compatible with OprD loss of functions/down-regulation.