Table 4.
Phenotypic antibiogram of clinical strain P. aeruginosa, compatible with an overexpression of MexXY-OprM, probably associated with the overexpression of OprH.
| P. aeruginosa | Blood Culture | |
|---|---|---|
| Antibiotic | MIC | SIR * |
| Aztreonam | ≤8 | S |
| Amikacin | >16 | R |
| Tobramycin | >2 | R |
| Cefepime | 16 | R |
| Ceftazidime | ≤2 | I |
| Ceftazidime/Avibactam | ≤2.0 | S |
| Ceftolozane/Tazobactam | ≤1.0 | S |
| Ciprofloxacin | >0.5 | R |
| Levofloxacin | >2 | R |
| Colistin | >4 | R |
| Imipenem | ≤1 | I |
| Meropenem | ≤0.125 | S |
| Piperacillin/Tazobactam | 8 | I |
MIC = minimum inhibitory concentration; SIR = Susceptible (S), Susceptible, Iincreased Eexposure (I), and Resistant (R).* Breakpoint sec. Clinical breakpoints (v 13.1) [44].Comment: phenotype resistance to aminoglycosides, cefepime, fluoroquinolones and colistin, susceptibility to other common β-lactams. This phenotype is compatible with an overexpression of MexXY-OprM associated with the overexpression of OprH, which is notable due to the resistance to colistin.