Table 1.
Characteristics of distinct EPC subtypes in cultures [13].
| Lineage | Myeloid Angiogenic Cells | Endothelial Colony-Forming Cells |
|---|---|---|
| positive cell markers | CD45, CD31, CD14 | CD31, CD105, CD 146 VE-cadherin, von Willebrand factor, VEGFR2 CD34+/− |
| negative cell markers | CD146, CD34 | CD45, CD14 |
| in vitro effects | conditioned media necessary for the endothelial formation | intrinsic tube forming capacity |
| function | provide paracrine angiogenic factors | provide cells as building blocks release of paracrine factors |
| time of appearance in culture | early | late |