Table 4.
Laboratory parameters of the study participants. The values were all determined from blood with the exception of two values measured in collected urine. The values in bold are above the laboratory reference values for the respective value. Shown in each case is the median (Q1–Q3) or the percentage. p > 0.05, * p ≤ 0.05, ** p < 0.01, *** p < 0.001, and p > 0.05 compared to control. ° p ≤ 0.05, °°° p < 0.001 compared to HypWell.
| Control (n = 8) |
HypWell (n = 36) |
HypPoor (n = 28) |
HypAll (n = 64) |
|
|---|---|---|---|---|
| Kidney function | ||||
| eGFR [mL/min/1.73 m2] | 82 (77–88) | 75 (56–86) | 77 (57–89) | 75 (57–87) |
| Urea [mg/dL] | 23 (23–25) | 38 (28–48) ** | 35 (28–41) ** | 36 (28–46) *** |
| Creatinine [mg/dL] | 1.01 (0.78–1.06) | 0.89 (0.80–1.15) | 0.99 (0.77–1.20) | 0.96 (0.79–1.17) |
| 24 h urine collection | ||||
| Proteinuria [mg/d] | 71 (39−112) | 39 (39–100) | 190 (121–237) ° | 105 (39–216) |
| Albuminuria [mg/d] | 11 (11–11) | 11 (11–11) | 84 (21–165) **, °°° | 11 (11–97) p = 0.06 |
| RAAS | ||||
| Renin [ng/L] | 7.8 (6.9–10.1) | 11.6 (6.5–39.8) | 6.2 (2.5–15.4) | 9.2 (4.2–28.4) |
| Aldosterone [ng/L] | 45 (38–66) | 66 (39–119) | 52 (36–101) | 58 (37–117) |
| Aldosterone to renin ratio | 5.6 (4.9–8.5) | 4.2 (1.2–12.9) | 12.0 (2.3–16.4) | 7.4 (1.5–16.4) |
| Blood parameters | ||||
| HbA1c [%] | 5.6 (5.5–5.7) | 5.9 (5.6–6.4) | 6.0 (5.5–6.6) | 5.9 (5.5–6.5) |
| Cholesterol [mg/dL] | 236 (210–256) | 194 (160–221) * | 182 (146–224) * | 187 (158–221) ** |
| Triglycerides [mg/dL] | 142 (114–193) | 126 (104–217) | 122 (94–205) | 124 (98–214) |
| Uric acid [mg/dL] | 5.9 (5.1–7.8) | 5.8 (5.1–7.5) | 5.8 (5.1–7.8) | |
| Protein [g/dL] | 7.2 (6.9–7.5) | 7.1 (6.8–7.3) | 7.0 (6.8–7.3) | 7.0 (6.8–7.3) |
| NT-proBNP [pg/mL] | 41 (30–62) | 103 (48–434) * p = 0.08 | 154 (75–413) * | 109 (59–433) ** |
eGFR = estimated glomerular filtration rate, HbA1c = glycohaemoglobin, NT-proBNP = N-terminal propeptide of brain natiuretic peptide, RAAS = renin aldosterone angiotensin system.