Table 8.
Correlation analysis of the markers for oxidative stress, DNA damage, and clinical parameters. All rank correlation coefficients, according to Spearman ≥ 0.20, are shown with the respective number of cases (n) and significance level: * p ≤ 0.05, ** p < 0.01. eGFR is shown as a representative marker of kidney function, whereby the other parameters of kidney function from blood and collected urine not shown here also correlated significantly.
| Age | eGFR | NT-proBNP | Protein in Serum | BMI | Uric Acid | Cholesterol | Renin | |
|---|---|---|---|---|---|---|---|---|
| SHp | −0.64 ** n = 59 |
0.49 ** n = 58 |
−0.52 ** n = 55 |
0.39 ** n = 57 |
−0.29 n = 37 |
0.30 * n = 56 |
−0.28 * n = 55 |
|
| D-ROM | ||||||||
| 3-NT | 0.37 ** n = 67 |
−0.45 ** n = 66 |
0.39 ** n = 61 |
−0.28 * n = 64 |
0.36 * n = 44 |
−0.40 ** n = 64 |
0.31 * n = 59 |
|
| 8-oxo-dG | −0.52 ** n = 34 |
−0.61 ** n = 20 |
−0.21 n = 33 |
|||||
| 15-F2t-IsoP | 0.44 ** n = 34 |
0.35 * n = 34 |
−0.39 * n = 34 |
−0.27 n = 20 |
||||
| MDA | 0.26 n = 34 |
0.33 n = 34 |
−0.26 n = 34 |
−0.20 n = 20 |
0.24 n = 3 |
|||
| γ-H2AX | 0.21 n = 51 |
−0.40 ** n = 51 |
−0.32 * n = 50 |
|||||
| MN | −0.22 n = 21 |
−0.47 ** n = 32 |
||||||
| NA | −0.27 n = 32 |
−0.24 n = 32 |
−0.31 n = 21 |
0.25 n = 32 |
3-NT = 3-nitrotyrosin, 15-F2t-IsoP = 15-F2t-isoprostane, γ-H2AX = phosphorylated histone 2AX, BMI = body mass index, CRP = C-reactive protein, D-ROM = derivatives of reactive oxygen species, eGFR = estimated glomerular filtration rate, MDA = malondialdehyde, MN = micronuclei, NA = nuclear anomalies, NT-proBNP = N-terminal propeptide of brain natiuretic peptide, and SHp = free thiol groups in proteins.