Table 10.
Systolic blood pressure, markers for oxidative stress in the blood, and markers for DNA damage over time. Fup1 after 7 ± 2 months, Fup2 after 14 ± 2 months. Shown is the median (Q1-Q3) and the number of cases (n). p > 0.05, * p ≤ 0.05 compared to V1, ° p ≤ 0.05, °° p < 0.01 compared to Fup1.
| V1 (n = 16) | Fup1 (n = 16) | Fup2 (n = 11) | |
|---|---|---|---|
| Measurement in practice | |||
| Systolic pressure sitting [mmHg] | 152 (144–161) | 133 (131–150) | 135 (122–148) * |
| ABPM | |||
| Mean systolic pressure [mmHg] | 137 (130–157) | 136 (128–142) | 130 (128–149) |
| Systolic pressure day [mmHg] | 146 (134–162) | 140 (131–147) | 135 (133–154) |
| Systolic pressure night [mmHg] | 129 (120–146) | 125 (120–129) | 119 (115–128) |
| Markers of oxidative stress | |||
| SHp [µmol/L] | 294 (260–370) | 379 (295–478) | 379 (347–457) * |
| D-ROM [CARR U] | 64 (55–70) | 59 (46–69) | 70 (61–80) p = 0.07, °° |
| 3-NT [nM] | 966 (671–1311) | 1032 (699–2061) * | 1072 (685–1452) * |
| Markers of DNA damage | |||
| γ-H2AX-Foci/cell | 3.81 (3.69–4.20) | 3.90 (3.73–4.13) | 4.23 (3.90–4.38) |
| MN/1000 mononuclear cells | 0.75 (0.00–1.50) | 1.00 (0.50–1.75) | 1.00 (0.50–1.50) |
| NA/1000 mononuclear cells | 1.00 (0.00–2.00) | 0.50 (0.00–1.75) | 1.50 (0.50–2.00) ° |
Fup = follow-up, 3-NT = 3-nitrotyrosin, γ-H2AX = phosphorylated histone 2AX, ABPM = ambulatory blood-pressure monitoring, D-ROM = derivatives of reactive oxygen species, MN = micronuclei, NA = nuclear anomalies, SHp = free thiol groups in proteins.