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. 2023 Nov 20;12(22):2667. doi: 10.3390/cells12222667

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Extracellular space (ECS) fraction and molecular transport, physical background. (a) The diffusion flux is proportional to the channel cross-section if the concentration difference is constant. However, if the amount of substance is constant, then increasing the volume of the channel will not increase the flow. (b) The flow during advection (transport of particles by liquid) depends on the shape of the cross-section of the channels. (c) The specific choice of the approximating method is determined.