Table 1.
Binomial logistic regression models provide associations as odds ratios, OR (95% CI), for the relative abundance of 5 immune cell types (T-cells, B-cells, neutrophils, NK cells, and macrophages) and 2 cell processes (tumor proliferation and interferon signaling), deconvoluted from the bulk transcriptome of the CBTN cohort. The first model contrasts high-grade tumors with low-grade tumors, and the second model contrasts the C4 immune subtype with C3, with significant associations indicated in bold. C4 tumors exhibit a lower T-cell signature and higher NK-cell, macrophage, and tumor-proliferation signatures, adjusting for histologic grade.
| High Grade/Low Grade | C4/C3 | |||||
|---|---|---|---|---|---|---|
| Characteristic | OR 1 | 95% CI 1 | p-Value | OR1 | 95% CI 1 | p-Value |
| T-Cells | 0.69 | 0.43, 1.09 | 0.11 | 0.36 | 0.20, 0.62 | <0.001 |
| Neutrophils | 1.01 | 0.81, 1.25 | >0.9 | 0.96 | 0.77, 1.20 | 0.7 |
| NK Cells | 0.84 | 0.79, 0.90 | <0.001 | 1.22 | 1.13, 1.32 | <0.001 |
| Macrophages | 0.90 | 0.60, 1.34 | 0.6 | 2.05 | 1.28, 3.31 | 0.003 |
| Proliferation | 7.12 | 5.41, 9.62 | <0.001 | 2.85 | 2.13, 3.91 | <0.001 |
| Interferon | 1.44 | 1.08, 1.94 | 0.013 | 1.19 | 0.86, 1.68 | 0.3 |
| Grade | ||||||
| Low | — | — | ||||
| High | 3.99 | 2.19, 7.48 | <0.001 | |||
1 OR = Odds Ratio, CI = Confidence Interval.