Figure 2.

Richter transformation in the skin of the left upper limb in a 78-year-old female patient with CLL lasting four years. The skin shows a conglomerate of merging red-blue tumors of various sizes with a necrotic scab in the center (A). Skin biopsy showing infiltration by diffuse large B-cell lymphoma in hematoxylin and eosin staining (B), in immunohistochemistry for CD20 (C), and Ki67 (D). Digital scans were obtained using Phillips IntelliSite UltraFast Scanner. (Philips, Amsterdam, The Netherlands.)