Figure 4.

Asymptomatic, multiple, variable-sized, erythematous tumors and papules are present on the face (A) and torso (B) of a 49-year-old patient with AML. The entire skin was thickened and infiltrated, with numerous red-blue tumors and nodules scattered over the entire surface. A particularly large, hard infiltrate is visible on the facial skin, where erythematous and exfoliative foci are also present on the basis of the nodular infiltrate (A,B). Biopsy of the skin showing infiltration by myeloblasts (hematoxylin and eosin staining in panels (C,D) under 25× and 200× magnification, respectively), which are positive for CD45 (LCA, 200× magnification, panel (E)), myeloperoxidase (200× magnification, panel (F)), and Ki-67 proliferation marker (200× magnification, panel (G)). The red box indicates area shown under larger magnification in panels (D–G).