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. 2023 Nov 7;30(11):9789–9812. doi: 10.3390/curroncol30110711

Table 4.

Small molecules in clinical trials.

Agent Target Clinical Trial Cancer Type Primary Objective
CA-170
Trial IDs:
CTRI/2017/12/011026 (phase II)
CTRI/2020/07/026870
(phase IIb/III)
PD-L1 Phase II Lymphoma ORR: 30%
PD-L1 Phase IIb/III Non-squamous, non-small cell lung cancer ORR: ongoing
INCB086550
Trial ID:
NCT04629339
PD-L1 Phase II Select solid tumors ORR: ongoing
CCX559
Trial ID:
ACTRN12621001342808
PD-L1 Phase I Solid tumors Safety