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Small molecules in preclinical studies.
| Small-Molecule Inhibitors in Preclinical Studies | ||
|---|---|---|
| Molecule | Immune Checkpoint | Pathways |
| SMI402 in tumor-bearing mice [91] | TIM-3 | Inhibition of tumor growth by increasing CD8+ T cell infiltration at tumor site |
| “Compounds 8 and 9” [92] | B7-1, preventing interaction with CTLA-4 | Lack of inhibition in a cell adhesion assay |
| Tubeimoside-1 (TBM-1) [89] | PD-L1 | Lysosomal degradation of PD-L1 in cancer cells via mTOR inactivation. |
