Table 3.

Potential Clinical Parameters for the Combination with CTC counts.

		Parameter	References
CTC-related	Atypical CTC subtypes:	Epithelial (E-CTCs), mesenchymal (M-CTCs), and partial epithelial/mesenchymal (pEMT-CTCs), stem cell like (SC-CTCs).	[51]
	CTC clusters:	Homotypic CTC clusters, heterotypic CTC clusters (CTC-immune, CTC-stroma cells).	[120]
Traditional medical testing (non-CTC-related)	Tumor blood markers	Alpha fetal protein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), cytokeratin fragment 21-1 (CYFRA21-1), squamous cell carcinoma antigen (SCC), prostate-specific antigen (PSA), carbohydrate antigen 15-3 (CA15-3), carbohydrate antigen 125 (CA125), human epididymis secretory protein 4 (HE 4), lactate dehydrogenase (LDH), thyroglobulin, neuron-specific enolase (NSE), nuclear matrix protein 22, prostatic acid phosphatase (PAP)…	[126,127,128,129,130]
	Tumor imaging data	X-ray imaging, computed tomography (CT), positron emission tomography (PET), ultrasound sonography (US), and nuclear magnetic resonance imaging (MRI).	[132]
	Patient’s physiological parameters	General survey (height, weight, gender, age); vital signs (blood pressure, body temperature); skin (skin moisture, dryness, temperature, color…); neck (palpate the cervical lymph nodes); back (palpate the spine and muscles) and various systematic examinations of the individual system	[133,134]
	Medical history	Personal medical history, past surgical history, family medical history, and social history.	[135]
	Cancer screening test	Fecal occult blood test (FOBT), Cologuard, Pap smear	[136,137,138,139]