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. 2023 Nov 20;15(22):5485. doi: 10.3390/cancers15225485

Table 2.

Intra-operative parameters and pathological features of the overall cohort.

Authors Surgical Approach
n (%)
Operative Time
(min)
Blood Loss
(mL)
Lymph Node Dissection
n (%)
≥pT3,
n (%)
sRP ISUP
≥4
n (%)
pN+
n (%)
PSM
n (%)
Complications *
n (%)
Kaouk et al. (2008) [13] RARP: 4 (100) 125 117 4 (100) NA 2 (67) 0 (0) 2 (50) 0 (0)
Liatsikos et al. (2008) [14] LRP: 12 (100) 153 238 8 (66) 4 (33) 5 (42) 0 (0) 3 (25) 1 (8)
Kim et al. (2008) [15] Open: 5 (71) RARP: 2 (29) 292 914 7 (100) 2 (28.5) NA NA 1 (14) 2 (28.5)
Boris et al. (2009) [16] RARP: 11 (100) 183 113 Standard template 7 (64)
Extended template 4 (36)
8 (73) 3 (27) 2 (18) 3 (27) 3 (27)
Seabra et al. (2009) [17] NA 80 300 NA 11 (26) 6 (14) NA NA Grade 3a: 21 (50)
Grade 3b: 2 (4.8)
Leonardo et al. (2009) [18] Open: 32 (100) 122 550 32 (100) 15 (5) 20 (6) 0 (0) 11 (3) 4 (12.5)
Nunez-Mora et al. (2009) [19] LRP: 9 (100) 170 250 9 (100) 5 (55.5) 6 (66) 2 (22) 2 (22) 2 (22)
Paparel et al. (2009) [20] NA NA NA NA NA 29 (20) 18 (13) 24 (16) NA
Heidenreich et al. (2010) [21] Open: 55 (100) 120 360 55 (100) 13 (24) 9 (20) 9 (20) 5 (11) Grade 1: 13 (23.6)
Grade 2: 2 (3.6)
Grade 3: 2 (3.6)
Strope et al. (2010) [22] RARP: 6 (100) 356 280 6 (100) 1 (16) NA 0 (0) 1 (16) 2 (34)
Eandi et al. (2010) [23] RARP: 18 (100) 156 150 18 (100) 9 (50) 4 (22) NA 5 (28) 7 (39)
Chauhan et al. (2011) [24] RARP: 15 (100) 138 75 12 (80) 10 (77) 7 (47) 1 (6.6) 2 (13) Grade 1: 1 (7)
Grade 2: 1 (7)
Grade 3: 1 (7)
Chade et al. (2011) [25] Open: 404 (100) NA NA 58 (14) NA 96 (24) 65 (16) 99 (25) NA
Gorin et al. (2011) [26] Open: 24 (100) NA 415 15 (63) 13 (54) NA 2 (13.3) 11 (46) NA
Ahallal et al. (2011) [27] Open: 11 (73)
RARP: 4 (27)
235 200 15 (100) 9 (60) 7 (47) 2 (13) 2 (13) Grade 1: 3 (20)
Grade 2: 2 (13)
Grade 3: 0 (0)
Lawrentschuk et al. (2011) [28] Open: 15 (100) 135 NA 13 (87) 9 (64) 4 (27) NA 4 (27) 1 (7)
Leonardo et al. (2012) [29] LRP: 12 (100) 220 150 13 (100) 8 (61.5) 2 (15) 0 (0) 2 (15) Grade 1: 3 (23)
Grade 2: 1 (8)
Grade 3: 2 (15)
Kaffenberger et al. (2013) [30] RARP: 34 (100) 176 NA 29 (85) 16 (47) 9 (26) N+: 0 (0)
Nx: 5 (15)
9 (26) Grade 1: 11 (32)
Grade 2: 1 (3)
Grade 3: 1 (3)
Peters et al. (2013) [31] Open: 44 (100) NA NA NA NA NA NA NA NA
Yuh et al. (2014) [32] RARP: 51 (100) 179 175 43 (84) 26 (51) 11 (21.6) 3 (6) 16 (31.4) Grade 1 2: 13 (25.5)
Grade 3 4: 22 (43)
Zugor et al. (2014) [33] RARP: 13 (100) 154 130 13 (100) 6 (46) 7 (54) 0 (0) 0 (0) Minor complications 4 (30.7)
Grade 1: 2 (15.3)
Grade 3a: 2 (15.3)
Major complications 0 (0)
Saeedi et al. (2014) [34] Open: 6 (100) NA NA 6 (100) 1 (17) 0 (0) 1 (17) 2 (33) 2 (33)
Bates et al. (2015) [11] RARP: 53 (100) 128
Console time: 80
100 NA 26 (49) 19 (36) NA 10 (19) Grade 1 2: 1 (2)
Grade 3 4: 0 (0)
Pokala et al. (2015) [35] NA NA NA 286 (79) 186 (51) NA 40 (11) NA NA
Pearce et al. (2015) [36] NA NA NA 273 (75) 169 (49) 19 (6.2) 122 (30) 124 (34) NA
Lebdai et al. (2015) [37] Open: 12 (63)
RARP: 5 (26)
LRP: 2 (11)
150 400 19 (100) 7 (37) 1 (5) 1 (5) 9 (47) Grade 1: 1 (5)
Grade 2: 1 (5)
Grade 3: 1 (5)
Mandel et al. (2016) [38] Open: 55 (100) NA 725 55 (100) 22 (40.5) 13 (23.6) 12 (22) 15 (27.5) Grade 3: 7 (12.7)
Vora et al. (2016) [39] RARP: 6 (100) NA NA NA NA NA NA NA 1 (16.7)
Kenney et al. (2016) [7] Open: 19 (49)
RARP: 20 (51)
297 623 39 (100) 24 (61.5) 18 (46) 5 (13) 6 (15) Grade 1 2: 43 (77)
Grade 3 4: 13 (23)
Orré et al. (2016) [40] RARP: 7 (100) 142 NA 2 (28.5) 5 (71) NA 4 (57) 1 (14) 2 (28.5)
Vidmar et al. (2017) [41] RARP: 12 (50)
Open: 12 (50)
180 300 4 (33) 7 (63) 4 (44) 1 (8) 6 (50) 0 (0)
Metcalfe et al. (2017) [42] NA NA NA 70 (100) 42 (60) 14 (20) 38 (54) 14 (20) NA
Ogaya-Pinies et al. (2019) [43] RARP: 96 (100) 125 100 85 (89) 22 (23) 8 (8) 29 (30) 16 (17) Grade 1: 20 (21)
Grade 2: 1 (1)
Grade 3: 3 (3)
Grade 4: 1 (1)
Onol et al. (2019) [44] RARP: 126 (100) 129
Console time: 84
107 94 (100) 47 (50) 40 (42.6) 10 (10.6) 16 (17) Clavien 1: 9 (9.7)
Clavien 2: 11 (11.8)
Clavien 3a: 2 (2.2)
Clavien 3b: 1 (1.1)
Clavien 4a: 1 (1.1)
Devos et al. (2019) [45] Open: 23 (92)
RARP: 2 (8)
166 808 23 (92) 14 (56) 12 (48) 7 (28) 11 (44) 22 (100)
Grade 1: 1 (4)
Grade 2: 5 (20)
Grade 3: 16 (64)
Mohler et al. (2019) [46] Open: 41 (100) 213 NA 41 (100) 23 (57) 24 (58.5) 5 (12) 7 (17) 44 (100)
Clery et al. (2019) [47] RARP: 44 (80)
Open: 11 (20)
150 300 55 (100) 31 (56) 15 (27) 6 (11) 4 (7) Grade 1: 44 (80)
Grade 2: 1 (1.8)
Grade 3: 2 (2.3)
Herrera-Caceres et al. (2019) [48] Open: 28 (82)
LRP: 1 (3)
RARP: 5 (15)
NA 512 34 (100) 20 (59) 2 (6) NA 13 (38) Intraoperative complications: Cystotomy 2 (6)
Gontero et al. (2019) [49] Open: 186 (47)
RARP: 209 (53)
221 468.5 337 (85) 217 (55) 170 (43) 63 (16) NA 146 (37)
De Groote et al. (2020) [50] RARP: 106 (100) 142 200 NA 70 (66) 23 (22) NA RT: 14 (52) 8 (8)
Grade 3a: 1 (1)
Nair et al. (2020) [51] Open: 4 (100) 210 866 4 (100) 3 (75) 1 (25) NA 2 (50) 1 (25)
Thompson et al. (2020) [52] RARP: 53 (100) Console time: 140 200 NA 34 (64.5) 5 (11) NA 23 (44) Grade 1: 4 (9)
Grade 2: 3 (7)
Grade 3: 1 (2)
Nathan et al. (2021) [53] RARP: 135 (100) 165 200 25 (18.5) 77 (57) 26 (29) NA 51 (38) Grade 1: 9 (7)
Grade 2: 7 (5)
Grade 3–5: 2 (1.5)
Madi et al. (2021) [12] RARP: 26 (100) 170.5 75 26 (100) 11 (42) 15 (58) 1 (4) 8 (31) 4 (15)
Grade 1: 1 (4)
Grade 2: 0 (0)
Grade 3: 3 (11)
Rajwa et al. (2021) [54] NA 198 600 214 (100) 159 (74) 86 (40.1) 40 (19) 43 (20) Grade 1: 21 (9.8)
Grade 2: 167 (78)
Grade 3: 26 (12)
Bozkurt et al. (2021) [55] RARP: 10 (100) 230.7 745 10 (100) 8 (80) 6 (60) 2 (20) 2 (20) Grade 1–2: 19 (90)
Grade 3–4: 5 (30)
Marra et al. (2021) [56] Open: 216 (52)
RARP: 198 (48)
186.5 300 349 (84.3) 218 (53) 151 (40) 65 (16.0) 122 (29.7) Grade 1–2: 144 (41.5)
Grade 3–4: 65 (19)
Spitznagel et al. (2021) [57] RARP: 13 (100) 260 230 13 (100) 3 (23) 1 (8) 1 (8) 1 (8) Grade 1: 2 (15)
Grade 2: 0 (0)
Grade 3: 4 (31)
Wenzel et al. (2021) [58] NA NA NA 428 (100) 47 (11) 17 (4) 24 (6) NA NA
von Hardenberg et al. (2021) [59] Open: 16 (36)
LRP: 3 (7)
RARP: 25 (57)
NA NA NA 14 (32) 16 (36) 3 (7) 10 (23) NA
Nathan et al. (2022) [60] RARP: 100 (100) 170 200 NA NA NA NA 38 (38) Grade 1: 6 (6)
Grade 2: 2 (2)
Grade 3: 1 (1)
Mortensen et al. (2022) [61] RARP: 5 (100) 205 120 0 (0) 3 (60) NA 3 (60) 3 (60) Grade 1: 3 (60)
Grade 2: 1 (20)
Van Riel et al. (2022) [62] LRP: 3 (8)
RARP: 36 (92)
NA 182 9 (23) 18 (46) 8 (21) 0 (0) 10 (26) NA
Blazevski et al. (2022) [63] RARP: 15 (100) NA 200 4 (27) 6 (40) 6 (40) 1 (7) 1 (7) 0 (0)
Catarino et al. (2022) [64] LRP: 29 (100) 90 200 25 (86) 19 (65.5) 13 (45) 5 (17) 8 (28) Grade 2: 4 (14)
Grade 3: 3 (10)

NA: not available, sRP: salvage radical prostatectomy, PSM: positive surgical margins, RT: radiation therapy. * According to classification of Clavien-Dindo.