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. 2023 Nov 9;12(22):4067. doi: 10.3390/foods12224067

Figure 7.

Figure 7

HCR-based electrochemical sensing platform for foodborne pathogen detection. (A) Dumbbell HCR combined with poly methylene blue nanoparticles. Reprinted with permission from ref. [69]. Copyright (2022) Elsevier. (B) Dendritic HCR combined with Fc-Dox. (a) the schematic diagram of the 3D DNA walker-based amplification reactions triggered by the target gene to produce many fragment of TN (FTN); (b) the schematic diagram of HCR and RCA-based amplification reactions on the electrode surface to generate to long double-stranded DNA sequences to immobilize many electrochemical indicators related with the concentration of target gene. (AuNPs, gold nanoparticles; BN, Blocking DNA; CT, Circular template; DW, DNA walker; FTN, fragment of TN; H1, hairpin DNA 1; H2, hairpin DNA 2; H3, hairpin DNA 3; HCR, hybridization chain reaction; MCH, 6-mercapto ethanol; RCA, rolling circle amplification; TN, transfer oligonucleotide) Reprinted with permission from ref. [70]. Copyright (2019) Elsevier. (C) A facile synthesis of silver wire on the electrode combined with AuNPs. Reprinted with permission from ref. [71]. Copyright (2020) Elsevier. (D) The reporter probe on the surface of the electrode was cleaved by HCR-CRISPR/Cas12a system. Reprinted with permission from ref. [72]. Copyright (2021) Springer Nature.