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. 2023 Nov 11;12(22):2611. doi: 10.3390/cells12222611

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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New model for the dynamics of CycB–Cdk1 shuttling in and out of the nucleus during interphase and its rapid nuclear re-entry to initiate male meiosis in Drosophila. The model illustrates the dynamics of CycB (orange) and Cdk1 (red) complex transport across the nuclear membrane (light gray) at the pre-meiotic stage when nuclear export via the Nup62 subcomplex in the NPCs continues (a). Subsequently, the CycB–Cdk1 complex with the modifications essential for meiotic initiation is transported back into the nucleus to trigger meiotic division (b).