Table 1.
Pain relief in conditions characterized by spasticity-related pain unresponsive to standard treatments, such as multiple sclerosis and spinal cord injuries [28,29,30,31]. | Nabiximols (THC and CBD 1:1 ratio) Bedrocan (THC 23% and CBD < 1%) |
Pain management in cases of chronic pain, particularly neurogenic pain, when treatment with non-steroidal anti-inflammatory drugs, corticosteroids, or opioids has demonstrated inefficacy [30]. | Nabiximols (THC and CBD 1:1 ratio) Nabilone (Synthetic cannabinoid derivate mimicking THC) |
The alleviation of nausea and vomiting induced by chemotherapy, radiotherapy, and anti-HIV therapies, which are unattainable through conventional treatments, is attributed to the antiemetic and antikinetic effects [29,30]. | Nabilone (Synthetic cannabinoid derivate mimicking THC) Dronabinol (synthetic form of Δ9-THC) |
Providing the capacity to stimulate appetite in conditions such as cachexia, anorexia, appetite loss in cancer patients or individuals with AIDS, and anorexia nervosa, which remains unattainable through conventional treatments [29]. | Dronabinol (synthetic form of Δ9-THC) |
The hypotensive effect in cases of glaucoma that do not respond to traditional treatments is observed [30]. | CBD derivatives |
Reduction in involuntary movements in Tourette syndrome, which cannot be achieved with standard treatments [32]. | Dronabinol (synthetic form of Δ9-THC) |
Reduction in seizure frequency associated with Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis complex [33,34]. | Highly purified CBD(>98% w/w) |
Alleviation of Parkinson-Disease-related tremor, anxiety, pain, and improvement of sleep quality and quality of life [35,36]. | CBD derivatives |