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. 2023 Nov 15;24(22):16380. doi: 10.3390/ijms242216380

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ZNF643 status in TCGA samples. (A) ZNF643 expression in normal (blue) and tumor (red) samples among distinct TCGA cohorts assessed with the UALCAN database. Statistical significance was calculated based on the student t-test. (B) Association between ZNF643 gene expression and p53 mutation status. Spearman’s correlation between ZNF643 gene expression and (C) tumor stage and (D) tumor grade. The data was downloaded from TISIDB database. The graphs on the left-hand side represent the p-values (transformed into –log10 p-values) as assessed with Spearman correlation test (NS: non-significant). Higher ZNF643 expression was observed in the tumors with lower (red) or higher (dark blue) (C) or grade (D). The tumors presenting statistically significant correlations are additionally shown on the barplots on the right. The scale from 1 to 4 on the X axis (C,D) denotes, respectively: the lowest and highest stage and grade. Adrenocortical carcinoma (ACC); bladder urothelial carcinoma (BLCA); breast invasive carcinoma (BRCA); cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC); cholangiocarcinoma (CHOL); colon adenocarcinoma (COAD); lymphoid neoplasm diffuse large B-cell lymphoma (DLBC); esophageal carcinoma (ESCA); glioblastoma multiforme (GBM); head and neck squamous cell carcinoma (HNSC); kidney chromophobe (KICH); kidney renal clear cell carcinoma (KIRC); kidney renal papillary cell carcinoma (KIRP); brain lower grade glioma (LGG); liver hepatocellular carcinoma (LIHC); lung adenocarcinoma (LUAD); lung squamous cell carcinoma (LUSC); mesothelioma (MESO); ovarian serous cystadenocarcinoma (OV); pancreatic adenocarcinoma (PAAD); prostate adenocarcinoma (PRAD); pheochromocytoma and paraganglioma (PCPG); rectum adenocarcinoma (READ); sarcoma (SARC); skin cutaneous melanoma (SKCM); stomach adenocarcinoma (STAD); testicular germ cell tumors (TGCT); thyroid carcinoma (THCA); thymoma (THYM); uterine corpus endometrial carcinoma (UCEC); uterine carcinosarcoma (UCS); uveal melanoma (UVM).