Table 2.
Functional categories enriched with DEGs in Galnt17−/− P14 cerebellum.
| Down-regulated category | -logPfdr | Example genes |
|---|---|---|
| response to growth factor | >10 | Arg1,Egr1,Folr1,Slit2,Ngfr,Sulf1,Tcf7l2 |
| transmembrane receptor protein serine/threonine kinase signaling pathway | 5.8 | Egr1,Folr1,Grem2,Igsf1,Msx1,Npnt,Sostdc1,Tcf7l2, Wfikkn2,Zcchc12 |
| heparan sulfate proteoglycan metabolic process | 5.7 | Hs3st2,Hs3st4,Ndst4,Sulf1,Tcf7l2 |
| neurotransmitter binding | 5.3 | Chrm2,Chrm3,Chrna4,Htr2c,Slc6a1 |
| regulation of axon guidance | 5.2 | Sema3b, Sema3f, Slit1, Slit2,Zswim4 |
| hormone binding | 5.2 | Chrm2,Chrm3,Chrna4,Ide,Prlr,Thrb,Ttr |
| modulation of chemical synaptic transmission | 5.1 | Baiap3,Chrm2,Chrna4,Egr1,Htr2c,Myob,Ngfr,Nptx2,Nptxr,Nrgn,Rasgrf2,Vgf |
| synaptic transmission, cholinergic | 5.2 | Chrm2,Chrm3,Chrna4,Htr2c,Ngfr |
| regulation of synapse organization | 4.8 | Camkv,Gpc4,Myo5b,Ngef,Nptxr,Pcdh8,Sema3f, Slit1,Tpbg |
| negative regulation of axon guidance | 4.7 | Sema3b,Sema3f,Slit1,Slit2 |
| Up-regulated category | Example genes | |
| positive regulation of intrinsic apoptotic signaling pathway | 5.0 | Bmf,Nox1,Rpl26,S100a9 |
| regulation of integrin biosynthetic process | 4.5 | Nox1,S100a9 |
Category enrichment and -log p fdr values were determined using the ToppCluster tool(Kaimal et al., 2010). The analysis was conducted with all DEGs reported in Table 1. Only the most highly significant and non-redundant gene ontology (GO) and Pathway categories detected by ToppCluster are shown