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. 2023 Nov 16;24(22):16412. doi: 10.3390/ijms242216412

Figure 1.

Figure 1

Mitochondrial MCviPi or MSssI overexpression increases mitochondrial GpC or CpG methylation, respectively. Modified frequency showing the per read per position frequency of CpG (A) or GpC (B) methylation in the mitochondrial genome of the different cell lines. WT and MCviPI mutants are both control cell lines with no expression (untransfected) or overexpression of an inactive DNMT (mock transfected), respectively. MCviPI overexpresses a GpC DNMT targeted to the mitochondrial genome; MSssI overexpresses a CpG DNMT targeted to the mitochondrial genome. Mitochondrial genes are represented as different colors on the x-axis.