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. 2023 Nov 16;24(22):16412. doi: 10.3390/ijms242216412

Figure 2.

Figure 2

Mitochondrial GpC hypermethylation specifically upregulates bile acid metabolism. (A) Heatmap representation of differentially expressed genes in three different HepG2 cell lines overexpressing a GpC DNMT MCviPI (MCviPI), a CpG DNMT (MSSSI), or overexpressing a GpC/CpG DNMT deficient MCviPI mutant. Cells were left untreated (none) or treated with 1 mM FFA for 24 h (FFA) to induce a MASLD phenotype in vitro. (B) Pathway enrichment analysis of four main differentially expressed gene clusters.